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KMID : 0370220030470010052
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Yakhak Hoeji
2003 Volume.47 No. 1 p.52 ~ p.55
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Comparisons of Antidiabetic Actlvities between White Ginseng Ethanol and IH-901 in Streptozotocin-Induced Diabetic Rats
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고성권/Ko SK
성종환/최용의/이충렬/박경수/정성현/Sung JH/Choi YE/Lee CR/Park KS/Chung SH
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Abstract
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Antidiabetic activities of white ginseng 50% ethanol extract (WGE) and IH901, an intestinal metabolite of ginsenoside Rbl, were compared in multiple low dose streptoz otocin (STZ)-induced diabetic rats. WGE or IH901 were coad-ministered with STZ on Day 1 at dose of 100 and 300 mg or 10 and 30 mg, respectively; and continually administered for 16 days. STZ dissolved in citrate buffer was injected intraperitoneally at dose of 20 mg/kg for 5 consecutive days. During the experiment, plasma glucose level and body weight were measured every 4th day. Amount of food and water intake were evaluated once a week and compared between groups. WGE and IH901 both significantly reduced the plasma glucose levels on Day 16 as compared with those of the diabetic control group. In the meantime, amount of food and water intake in WGE- and IH901-treated groups were significantly improved in a dose dependent fashion as compared with those of the diabetic control group. Taken together, WGE and IH901 showed the comparable antidiabetic activities at the corresponding doses used in this experiment.
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KEYWORD
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